Procaine hydrochloride is a drug. Procaine hydrochloride acts on peripheral nerves to produce conduction block. It penetrates the nerve cell membrane in a diffuse manner depending on the concentration gradient, blocks sodium ion channels on the inside, and increases the excitation threshold of nerve cells. High, loss of excitability and conductivity, information transmission is blocked, with good local anesthesia.
This product is an ester local anesthetic, which can temporarily block the conduction of nerve fibers and has anesthesia effect.
This product has poor dispersibility and permeability, and the combined form of its hydrochloride releases free base in tissues, which plays a role in local anesthesia. This product has a continuous inhibitory effect on the central nervous system and is overexcited. It first causes sedation, dizziness, and an increase in pain thresholds, followed by dizziness, disorientation, and ataxia.
The depression in the center continues to deepen, resulting in unconsciousness, confusion, and then into a coma. If the dose continues to increase, muscle tremors and irritability may occur. Intoxication symptoms of central excitation, such as irritability and convulsions.
Small doses of this product can excite sympathetic nerves and increase heart rate and blood pressure. When the dose was increased, blood pressure decreased and heart rate increased due to myocardial depression, peripheral vasodilation, and mild ganglionic block.
Procaine hydrochloride inhibits the release of acetylcholine from the presynaptic membrane, causing a certain block of muscle nerves, which can enhance the effect of non-depolarizing muscle relaxants, directly inhibit smooth muscle, and relieve smooth muscle spasm.